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Feb 26, 2015 The benefit of statins in the prevention of cardiovascular disease is well founded, derived from their lipid lowering and pleiotropic effects. Aug 11, 2013 Atrial fibrillation remains the most common arrhythmia in clinical practice. Dronedarone is an antiarrhythmic drug for the maintenance of sinus Pleiotropic Effects of Resistance-Breaking Mutations on Particle Stability Provide Insight into Life History Evolution of a Plant RNA Virus. Sayanta Bera, Manuel There were shown also to exist non-lipid-modifiable effects of statins called pleiotropic ones, which could be responsible for this additional benefit. The most The effects of deleting the QA motif were strong in some tissues but barely detectable in others.
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Relevant papers published after December 2010 were also included as As a result, the pleiotropic effects of m.4295A>G mutation on tRNA Ile metabolism including the processing of tRNA precursors, stability and aminoacylation of tRNA Ile contributed to marked reductions in the steady-state level of tRNA Ile, in contrast with mild reductions in tRNA Asp and tRNA Met observed in the cell lines bearing the m.7551A>G and m.4435A>G mutations (31, 32). Pleiotropic preventive effects of dietary polyphenols in cardiovascular diseases. Y Kishimoto 1, M Tani 1 & K Kondo 1 Pleiotropic Effects of GIP on Islet Function Involve Osteopontin. Research output: Contribution to journal › Article Welcome to the Goodman Learning. In this video Dr. Sean McManus explains the genetic concept of pleiotropy.We explore the concept of pleiotropy with specific The pleiotropic effects of vitamin D and associated mechanisms are summarized in Table 1. In addition, the paracrine and autocrine effects of vitamin D have a protective role in many diseases.
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de Jaime-Soguero A(1), Abreu de Oliveira WA(2), Lluis F(3). Author information: (1)Stem Cell Signalling Laboratory, Department of Development and Regeneration, KU Leuven Stem Cell Institute, Herestraat 49, Onderwijs en Navorsing 4, Box 804, 3000 Leuven Pleiotropic: Producing or having multiple effects from a single gene.
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Good overview of pleiotropic effects. Statins may have good effects for Alzheimer's and Parkinson's disease, infection management, and traumatic brain injury and spinal cord injury. 2015-12-08 2002-04-01 Recent experimental evidence supports the premise that clinical benefits are related primarily to pleiotropic effects of statins (endothelial function, inflammation, coagulation and plaque vulnerability). 2021-01-28 the production by a single gene of multiple phenotypic effects. The term is often used to refer to a single gene defect that is expressed as problems in multiple systems of the body, such as in osteogenesis imperfecta, where the gene causes defects in several different systems that contain collagen.
Galectin-3. Most biomedical reports of MCP focus specifically on its antagonism of galectin-3 (Gal-3).
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2015-12-17 · V. PLEIOTROPIC ACTIONS OF VITAMIN D. Over the course of the last decades, it has become increasingly clear that the effects of 1,25(OH) 2 D 3 are not limited to the maintenance of calcium and phosphate homeostasis. The Pleiotropic Effects of a Drug . In defense of the care providers in such settings, they feel tremendous pressure from the patients who come to see them that "they want what they want." Thus, it is not surprising that mutations in genes which function in melanocyte development or melanogenesis frequently cause pleiotropic effects involving sight, hearing and neurologic functioning. Many pleiotropic effects recently studied in mice have come from investigating mutagenesis screens and knockout mutations. Pleiotropic effects of_statins 1.
2021-01-28 · Based on numerous studies detailing the beneficial effects of prebiotic GOS, which include modulation of the gut microbiome with specific increases in beneficial bacteria [45, 47], stimulation of tight junctions and enhancement of the intestinal barrier function through modulation of goblet cells , reduction of inflammatory markers release in cell culture models , support of intestinal development and mucosal immune responses , and reduction in adherence of enteropathogenic
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Pleiotropic: Producing or having multiple effects from a single gene. For example, the Marfan gene is pleiotropic, potentially causing such diverse effects as long fingers and toes (arachnodactyly), dislocation of the lens of the eye, and dissecting aneurysm of the aorta. CONTINUE SCROLLING OR CLICK HERE
Indeed, recent studies indicate that some of the cholesterol-independent or “pleiotropic” effects of statins involve improving endothelial function, enhancing the stability of atherosclerotic plaques, decreasing oxidative stress and inflammation, and inhibiting the thrombogenic response.
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Many pleiotropic effects recently studied in mice have come from investigating mutagenesis screens and knockout mutations. pleiotropy [pli-ot´rŏ-pe] the production by a single gene of multiple phenotypic effects. The term is often used to refer to a single gene defect that is expressed as problems in multiple systems of the body, such as in osteogenesis imperfecta, where the gene causes defects in several different systems that contain collagen. Miller-Keane Encyclopedia 2007-06-01 2020-09-01 2015-12-17 Many of these pleiotropic effects are mediated by inhibition of isoprenoids, which serve as lipid attachments for intracellular signaling molecules.
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Pleiotropic effects… 2019-09-24 Statins could be one of those due to their pleiotropic effects on inflammation and fibrosis, in addition to the antihyperlipidemic effect they are used more commonly for. Statins Pleiotropy.